Wahl Lab

Wahl Lab - Current Publications

Current Publications | 2004-2006 | 2000-2003 | 1998-2000 | 1996-1998 | 1994-1996 | 1986-1993 | 1970-1986

  1. Wade, M., and Wahl, G.M. (2006) C-myc, genome instability, and tumorigenesis: the devil is in the details.  Curr. Top. in Microbiol. and Immunol. 302:169-203. [PDF]
  2. Wahl, G.M. (2006) Mouse bites dogma: how mouse models are changing our views of how p53 is regulated in vivo.  Cell Death and Differention 13:973-983. [PDF]
  3. Toledo, F. and Wahl, G.M. (2006) Regulating the p53 pathway: in vitro hypotheses, in vivo veritas.  Nat. Rev. Canc. 6:909-923. [PDF]
  4. Wade, M., Wong, E.T., Tang, M., Stommel, J.M. and Wahl, G.M. (2006) Hdmx modulates the outcome of p53 activation in human tumor cells.  J Biol. Chem. 281(44):33036-33044. [PDF]
  5. Toledo, F., Lee, C.J., Krummel, K.A., Liu, C.W., Rodewald, L.W., and Wahl, G.M. (2007) Mouse mutants reveal that putative protein interaction sites in the p53 proline-rich domain are dispensable for tumor suppression. Mol Cell Biol. 27(4):1425–1432. doi: 10.1128/MCB.00999-06. [PDF]
  6. Toledo, F. and Wahl, G.M. (2007) MDM2 and MDM4: p53 regulators as targets in anticancer therapy. International J Bio. & Cell Biol. 39:1476-1482. [PDF]
  7. Wang, Y.V., Wade, M., Wong, E.T., Li, Y-C., Rodewald, L.W., and Wahl, G.M. (2007) Quantitative analyses reveal the importance of regulated Hdmx degradation for p53 activation.  Proc. Natl. Acad. Sci. Published online before print July 17, 2007, 10.1073/pnas.0701497104. [PDF]
  8. Wade, M., Rodewald, L.W., Espinosa, J.M., and Wahl, G.M. (2008) BH3 activation blocks Hdmx suppression of apoptosis and co-operates With Nutlin to induce cell death. Cell Cycle. 1:7(13):1973-82. [PDF]
  9. Wade, M., and Wahl, G.M. (2009). Targeting mdm2 and mdmx in cancer: better living through medicinal chemistry? Mol Cancer Res 7(1): 1-11. [PDF]
  10. Wang, Y.V., Leblanc, M., Wade, M., Jochemsen, A.G., and Wahl, G.M. (2009) Increased radio-resistance and accelerated B-cell lymphomas in mice with Mdmx mutations that prevent modifications by DNA damage-activated kinases.  Cancer Cell 16: 33-43. PMCID: PMC2758524 [PDF]
  11. Kawamura, T., Suzuki, J., Wang, Y.V., Menendez, S., Morera, L.B., Wahl, G.M, and Belmonte, J.C. (2009) Linking the p53 pathway to somatic cell reprogramming.  Nature 460: 1140-1144. PMCID: PMC2735889. [PDF]
  12. Wang, Y.V., Wade M and Wahl GM (2009). Guarding the Guardian: Mdmx plays important roles in setting p53 basal activity and determining biological responses in vivo.  Cell Cycle 8 (21): 3443-3444. .PMCID: PMC2777705. [PDF]
  13. Ponnamperuma, R.M., King, K.E., Elsir, T., Glick, A.B., Wahl, G.M., Nister, M., and Weinberg, W.C. (2009) The transcriptional regulatory function of p53 is essential for suppression of mouse skin carcinogenesis and can be dissociated from effects on TGF-ß-mediated growth regulation.  Journal of Pathology 219: 263–274. NIHMSID # 146961. [PDF]
  14. Wang, Y.V., Wade M and Wahl GM (2010). The p53 orchestra: Mdm2 and Mdmx set the tone.  Trends in Cell Biology. May;20(5):299-309. PMCID: PMC2910097. [PDF]
  15. Mizuno, M., Benjamin T. Spike, Wahl, G.M., and Levine, A.J. (2010) p53 Inactivation in Breast Cancers Correlates with Stem Cell Transcriptional Signatures.  PNAS: 107(52): 22745–22750. PMCID: PMC3012457 [PDF]
  16. Bernal F, Wade M, Godes M, Davis TN, Whitehead DG, Kung AL, Wahl GM, Walensky LD. A Stapled p53 Helix Overcomes HDMX-Mediated Suppression of p53. Cancer Cell. 2010 18:411-22. PMCID: PMC3050021 [PDF]
  17. Wang, Y.V., Fox, N., Leblanc, M., Mao, J., Balmain, A., Kaushansky, K., and Wahl, G.M. (2011) Fine tuning p53 activity is a critical determinant of stem cell homeostasis and radiosensitivity in the hematopoietic system. Genes Dev Jul 1;25(13):1426-38. PMCID: PMC3134085 [PDF]
  18. Benjamin T. Spike and Wahl, G.M. (2011) p53, Stem Cells, and Reprogramming: Tumor Suppression beyond Guarding the Genome. Genes Cancer. 2011 April; 2(4): 404–419. PMCID: PMC3135646 [PDF]
  19. Wade, M., Li, Y-C., Matani, A., Braun, S., Milanesi, F., Rodewald, L.W., and Wahl, G.M. (2012) Functional analysis and consequences of Mdm2 E3 ligase inhibition in human tumor cells. . Oncogene (January 23 - online) 1-9. PMCID: PMC3337965 [PDF]
  20. Spike, B.T.*, Engle, D.*, Lin, J.*, Cheung, S., La, J., and Wahl, G.M. (2012) A mammary stem cell population identified and characterized in late embryogenesis reveals similarities to human breast cancer. *equal contribution  Cell-Stem-Cell. Volume 10, Issue 2, 183-197. PMCID: PMC3277444 [PDF]
  21. Lee, J-H, Jin, Y., He, G., Zeng, S., Wang, V., Wahl, G.M., and Lu, H. (2012) Hypoxia activates p53 through the ATR-Chk1-MDMX-14-3-3g pathway.  JCB (in press) [PDF]
  22. Li, Y.C. and Wahl. G.M. (2012). What a difference a phosphate makes: Life or death decided by a single amino acid in Mdm2. Cancer Cell 21:595-596 [PDF]
  23. Green, J.L., Bauer, M. Yum, K.W., Li, Y-C., Cox, M.L., Willert, K., and Wahl, G.M. (2013) Use of a Molecular Genetic Platform Technology to Produce Human Wnt Proteins Reveals Distinct Local and Distal Signaling Abilities. PLoS One, 8(3):e58395. PMCID: PMC3596392 [PDF]
  24. Green, J.L., La, J., Yum, K.W., Desai, P., Rodewald, L.W., Zhang, X., Leblanc, M., Nusse, R., Lewis, M.T., and Wahl, G.m. (2013). Paracrine Wnt signaling both promotes and inhibits human breast tumor growth. Proc. Natl. Acad. Sci. U.S.A. 110(17):6991-6 (PMCID: In Process) [PDF]
  25. Makarem, M., Spike, B.T., Dravis, C., Kannan, N., Wahl, G.M., and Eaves, C.J. (2013) Stem cells and the developing mammary gland. J Mammary Gland Biol Neoplasia, 18(2):209-19. doi: 10.1007/s10911-013-9284-6. Epub 2013 Apr 27. (PMCID in process) [PDF]
  26. Rasmussen, N.R., Wright, T.M., Brooks, S.A., Hacker, K.E., Debebe, Z., Sendor, A.B., Walker, M.P., Major, M.B., Green, J., Wahl, G.M., and Rathmell, W.K. (2013) Receptor tyrosine kinaselike orphan receptor 2 (Ror2) expression creates a poised state of Wnt signaling in renal cancer. J Biol Chem., 288(36):26301-10. doi: 10.1074/jbc.M113.466086. Epub 2013 Jul 26. PMCID: PMC3764835 [PDF]
  27. He, G-F., Xhang, Y-W., Lee, J-H., Zeng, S., Wang, Y-Y., Luo, Z., Dong, C., Viollet, B., Wahl, G.M., and Lu, H. (2013) AMP-activated protein kinase induces p53 by phosphorylating MDMX and inhibiting its activity. Mol Cell Biol., 34(2):148-57. doi: 10.1128/MCB.00670-13. Epub 2013 Nov 4. PMCID: PMC3911293 [PDF]
  28. Pfefferle, A.D., Herschkowitz, J.I., Usary, J., Harrell, J.C., Spike, B.T., Adams, J.R., Torres-Arzayus, M.I., Brown, M., Egan, S.E., Wahl, G.M., Rosen, J.M., and Perou, C.M. (2013) Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts. Genome Biol. 14(11):R125 epub ahead of print. PMCID in progress [PDF]
  29. Spike, B.T., Kelber, J.A., Booker, E., Kalathur, M., Rodewald, R., Lipianskaya, J., La, J., He, M., Wright, T., Klemke, R., Wahl, G.M., and Gray, P.C. (2014) CRIPTO/GRP78 Signaling Maintains Fetal and Adult Mammary Stem Cells Ex Vivo. Stem Cell Reports. 2(4):427-39. doi: 10.1016/j.stemcr.2014.02.010. PMCID: PMC3986630 [PDF]
  30. Li, Y-C., Rodewald, L.W., Hoppmann, C., Wong, E.T., Lebreton, S., Safar, P., Patek, M., Wang, L., Wertman, K.F., and Wahl, G.M. (2014) ReBil, a versatile platform technology to analyze protein-protein interactions in living cells in real time. Submitted
  31. Rozhok, A.L., Wahl, G.M. and DeGregori, J. (2015) A critical examination of the "bad luck" explanation of cancer risk. Cancer Prev Res (Phila). 2015 Jun 29. Pii: canprevres.0229.2015. [Epub ahead of print]
  32. Dravis, C., Spike, B.T., Harrell, C.J., Johns, C., Trejo, C., Southard-Smith, M.E., Perou, C.M. and Wahl, G.M. (2015) Sox10 regulates stem cell and mesenchymal states in mammary epithelial cells. Cell reports, pii: S2211-1247(15)00925-0. [Epub ahead of print]
  33. Adams, C.J., Yu, J.S., Mao, J., Jen, K., Sylvain, V., Wade, M., Shoemake, J., Aina, O.H., Del Rosario, R., Menchavez, P.T., Cardiff, R.D., Wahl, G.M. and Balmain, A. (2015) The Trp53 delta proline (Trp53∆P) mouse exhibits increased genome instability and susceptibility to radiation-induced, but not spontaneous, tumor development. Molecular Carcinogenesis. In press.
  34. Wahl, G.M., Spike, B.T. (2017) Cell state plasticity, stem cells, EMT, and the generation of
    intra-tumoral heterogeneity. npj Breast Cancer (2017) 3:14 ; doi:10.1038/s41523-017-0012-z [PDF]
  35. Turner, K.M., Deshpande, V., Beyter, D., Koga, T., Rusert, J., Lee, C., Li, B., Arden,K., Ren,B., Nathanson, D.A., Kornblum, H.I., Taylor, M.D., Kaushal, S., Cavenee, W. K., Wechsler-Reya, R., Furnari, F.B., Vandenberg, S.R., Rao, P.N., Wahl, G.M., Bafna, V., and Mischel, P.S. (2017) Extrachromosomal oncogene amplification drives tumor evolution and genetic heterogeneity. Nature. 2017 March 02; 543(7643): 122–125. doi:10.1038/nature21356. [PDF]
  36. Trejo, C.L., Luna, G., Dravis, C., Spike, B.T., and Wahl, G.M. (2017) Lgr5 is a marker for fetal mammary stem cells, but is not essential for stem cell activity or tumorigenesis. npj Breast Cancer (2017) 3:16 ; doi:10.1038/s41523-017-0018-6 [PDF]