Publications

Publications

  1. Saison-Ridinger, M., DelGiorno, K.E., Zhang, T., Kraus, A., French, R., Jaquish, D., Tsui, C., Erikson, G., Spike, B.T., Shokhirev, M.N., Liddle, C., Yu, R.T., Downes, M., Evans, R.M., Saghatelian, A., Lowy, A.M., Wahl, G.M. (2017)  Reprogramming pancreatic stellate cells via p53 activation: A putative target for pancreatic cancer therapy. PLos One 12(12):e0189051. doi: 10.1371/journal.pone.0189051. PMCID:PMC5718507
  2. Trejo, C., Luna, G., Dravis, C., Spike, B. and Wahl, G.M. (2017) Lgr5 is a marker for fetal mammary stem cells, but is not essential for stem cell activity or tumorigenesis. NPJ Breast Cancer, 3:16. NIHMS: 873810, PMCID: PMC5460261. doi:10.1038/s41523-017-0018-6 [PDF]
  3. Wahl, G.M. and Spike, B.T. (2017) Cell state plasticity, stem cells, EMT, and the generation of intra-tumoral heterogeneity. NPJ Breast Cancer, 3:14. PMCID: PMC5460241. doi:10.1038/s41523-017-0012-z [PDF]
  4. Turner, K.M., Deshpande, V., Beyter, D., Koga, T., Rusert, J., Lee, C., Li, B., Arden, K., Ren, B., Nathanson. D.A., Kornblum, H.I., Taylor, M.D., Kaushal, S., Cavenee. W.K., Wechsler-Reya, R., Furnari, F.B., Vandenberg, S.R., Rao, P.N., Wahl, G.M., Bafna, V., Mischel, P.S. (2017) Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity. Nature. 543(7643):122-125. PMCID: PMC5334176 [PDF]
  5. Sancho-Martinez, I., Nivet, E., Xia, Y., Hishida, T., Aguirre, A., Ocampo, A., Ma, L., Morey, R., Krause, M.N., Zembrzycki, A., Ansorge, O., Vazquez-Ferrer, E., Dubova, I., Reddy, P., Lam, D., Hishida, Y., Wu, M.-Z., Rodriguez Esteban, C., O’Leary, D., Wahl, G.M., Verma, I. M., Laurent, L. C. and Izpisua Belmonte, J.C. (2016) Establishment of human iPSC-based models for the study and targeting of glioma initiating cells. Nature Communications. 7:10743. PMCID: PMC4764898
  6. Adams, C.J., Yu, J.S., Mao, J., Jen, K., Sylvain, V., Wade, M., Shoemake, J., Aina, O.H., Del Rosario, R., Menchavez, P.T., Cardiff, R.D., Wahl, G.M. and Balmain, A. (2016) The Trp53 delta proline (Trp53?P) mouse exhibits increased genome instability and susceptibility to radiation-induced, but not spontaneous, tumor development. Molecular Carcinogenesis, 55(9):1387-96. PMCID: PMC4891300
  7. Rozhok, A.L., Wahl, G.M. and DeGregori, J. (2015) A critical examination of the “bad luck” explanation of cancer risk. Cancer Prev Res (Phila), 8(9):762-4. PMCID: PMC4849411 [Epub ahead of print]
  8. Dravis, C., Spike, B.T., Harrell, C.J., Johns, C., Trejo, C., Southard-Smith, M.E., Perou, C.M. and Wahl, G.M. (2015) Sox10 regulates stem cell and mesenchymal states in mammary epithelial cells. Cell reports, pii: S2211-1247(15)00925-0. PMCID: PMC4591253 [Epub ahead of print]
  9. Pfefferle, A.D., Spike, B.T., Wahl, G.M. and Perou, C.M. (2015) Luminal progenitor and fetal mammary stem cell expression features predict breast tumor response to neoadjuvant chemotherapy. Breast Cancer Res Treat., 149: 425–437. PMCID: PMC4308649
  10. Li, Y-C., Rodewald, L.W., Hoppmann, C., Wong, E.T., Lebreton, S., Safar, P., Patek, M., Wang, L., Wertman, K.F., and Wahl, G.M. (2014) A versatile platform to analyze low-affinity and transient protein-protein interactions in living cells in real time. Cell Reports, 9(5):1946-58. doi: 10.1016/j.celrep.2014.10.058. Epub 2014 Nov 20. PMCID: PMC4269221
  11. Sherman, M.H., Yu, R.T., Engle, D.D., Ding, N., Atkins, A.R., Tiriac, H., Collisson, E.A., Connor, F., Van Dyke, T., Kozlov, S., Martin, P., Tseng, T.W., Dawson, D.W., Donahue, T.R., Masamune, A., Shimosegawa, T., Apte, M.V., Wilson, J.S., Ng, B., Lau, S.L., Gunton, J.E., Wahl, G.M., Hunter, T., Drebin, J.A., O’Dwyer, P.J., Liddle, C., Tuveson, D.A., Downes, M. and Evans, R.M. (2014) Vitamin d receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy. Cell, 159(1):80-93. doi: 10.1016/j.cell.2014.08.007. PMCID: PMC4177038
  12. Spike, B.T., Kelber, J.A., Booker, E., Kalathur, M., Rodewald, R., Lipianskaya, J., La, J., He, M., Wright, T., Klemke, R., Wahl, G.M., and Gray, P.C. (2014) CRIPTO/GRP78 Signaling Maintains Fetal and Adult Mammary Stem Cells Ex Vivo. Stem Cell Reports. 2(4):427-39. doi: 10.1016/j.stemcr.2014.02.010. PMCID: PMC398663 [PDF]
  13. Pfefferle, A.D., Herschkowitz, J.I., Usary, J., Harrell, J.C., Spike, B.T., Adams, J.R., Torres-Arzayus, M.I., Brown, M., Egan, S.E., Wahl, G.M., Rosen, J.M., and Perou, C.M. (2013) Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts. Genome Biol. 14(11):R125 epub ahead of print. PMCID:PMC4053990 [PDF]
  14. He, G-F., Xhang, Y-W., Lee, J-H., Zeng, S., Wang, Y-Y., Luo, Z., Dong, C., Viollet, B., Wahl, G.M., and Lu, H. (2013) AMP-activated protein kinase induces p53 by phosphorylating MDMX and inhibiting its activity. Mol Cell Biol., 34(2):148-57. doi: 10.1128/MCB.00670-13. Epub 2013 Nov 4. PMCID: PMC3911293 [PDF]
  15. Rasmussen, N.R., Wright, T.M., Brooks, S.A., Hacker, K.E., Debebe, Z., Sendor, A.B., Walker, M.P., Major, M.B., Green, J., Wahl, G.M., and Rathmell, W.K. (2013) Receptor tyrosine kinase-like orphan receptor 2 (Ror2) expression creates a poised state of Wnt signaling in renal cancer. J Biol Chem., 288(36):26301-10. doi: 10.1074/jbc.M113.466086. Epub 2013 Jul 26. PMCID: PMC3764835 [PDF]
  16. Makarem, M., Spike, B.T., Dravis, C., Kannan, N., Wahl, G.M., and Eaves, C.J. (2013) Stem cells and the developing mammary gland. J Mammary Gland Biol Neoplasia, 18(2):209-19. doi: 10.1007/s10911-013-9284-6. Epub 2013 Apr 27. PMCID:PMC4161372 [PDF]
  17. Green, J.L., La, J., Yum, K.W., Desai, P., Rodewald, L.W., Zhang, X., Leblanc, M., Nusse, R., Lewis, M.T., and Wahl, G.M. (2013). Paracrine Wnt signaling both promotes and inhibits human breast tumor growth. Proc. Natl. Acad. Sci. U.S.A. 110(17):6991-6 PMCID:PMC3637696 [PDF]
  18. Green, J.L., Bauer, M. Yum, K.W., Li, Y-C., Cox, M.L., Willert, K., and Wahl, G.M. (2013) Use of a Molecular Genetic Platform Technology to Produce Human Wnt Proteins Reveals Distinct Local and Distal Signaling Abilities. PLoS One, 8(3):e58395. PMCID: PMC3596392 [PDF]
  19. Wade, M., Li, Y.C. and Wahl, G.M. (2012). MDM2, MDMX and p53 in oncogenesis and cancer therapy. Nature Reviews Cancer, 13(2):83-96. PMCID: PMC4161369
  20. Li, Y.C. and Wahl. G.M. (2012). What a difference a phosphate makes: Life or death decided by a single amino acid in Mdm2. Cancer Cell 21:595-596. [PDF]
  21. Lee, J-H, Jin, Y., He, G., Zeng, S., Wang, V., Wahl, G.M., and Lu, H. (2012) Hypoxia activates p53 through the ATR-Chk1-MDMX-14-3-3? pathway. JCB 15;287(25):20898-903. PMCID: PMC3375513 [PDF]
  22. Spike, B.T., Engle, D., Lin, J., Cheung, S., and Wahl, G.M. (2012) A mammary stem cell population identified and characterized in late embryogenesis reveals similarities to human breast cancer. Cell-Stem-Cell. Volume 10, Issue 2, 183-197. PMCID: PMC3277444 [PDF]
  23. Wade, M., Li, Y-C., Matani, A., Braun, S., Milanesi, F., Rodewald, L.W., and Wahl, GM (2012) Functional analysis and consequences of Mdm2 E3 ligase inhibition in human tumor cells. Oncogene (January 23 – online) 1-9. PMCID: PMC3337965 [PDF]
  24. Benjamin T. Spike and Wahl, G.M. (2011) p53, Stem Cells, and Reprogramming: Tumor Suppression beyond Guarding the Genome. Genes Cancer. 2011 April; 2(4): 404–419. PMCID: PMC3135646 [PDF]
  25. Wang, Y.V., Leblanc, M., Fox, N., Mao, J.H., Tinkum, K.L., Krummel, K., Engle, D., Pinwica-Worms, D., Pinwica-Worms, H., Balmain, A., Kaushansky, K., and Wahl, G.M. (2011) Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity. . Genes Dev Jul 1;25(13):1426-38. PMCID: PMC3134085 [PDF]
  26. Bernal F, Wade M, Godes M, Davis TN, Whitehead DG, Kung AL, Wahl GM, Walensky LD. A Stapled p53 Helix Overcomes HDMX-Mediated Suppression of p53. Cancer Cell. 2010 18:411-22. PMCID: PMC3050021 [PDF]
  27. Mizuno, M., Benjamin T. Spike, Wahl, G.M., and Levine, A.J. (2010) p53 Inactivation in Breast Cancers Correlates with Stem Cell Transcriptional Signatures. PNAS: 107(52): 22745–22750. PMCID: PMC3012457 [PDF]
  28. Wang, Y.V., Wade M and Wahl GM (2010). The p53 orchestra: Mdm2 and Mdmx set the tone. Trends in Cell Biology. May;20(5):299-309. PMCID: PMC2910097. [PDF]
  29. Ponnamperuma, R.M., King, K.E., Elsir, T., Glick, A.B., Wahl, G.M., Nister, M., and Weinberg, W.C. (2009) The transcriptional regulatory function of p53 is essential for suppression of mouse skin carcinogenesis and can be dissociated from effects on TGF-?-mediated growth regulation. Journal of Pathology 219: 263–274. NIHMSID # 146961. [PDF]
  30. Wang, Y.V., Wade M and Wahl GM (2009). Guarding the Guardian: Mdmx plays important roles in setting p53 basal activity and determining biological responses in vivo. Cell Cycle 8 (21): 3443-3444. . PMCID: PMC2777705. [PDF]
  31. Kawamura, T., Suzuki, J., Wang, Y.V., Menendez, S., Morera, L.B., Wahl, G.M, and Belmonte, J.C. (2009) Linking the p53 pathway to somatic cell reprogramming. Nature 460: 1140-1144. PMCID: PMC2735889. [PDF]
  32. Wang, Y.V., Leblanc, M., Wade, M., Jochemsen, A.G., and Wahl, G.M. (2009) Increased radio-resistance and accelerated B-cell lymphomas in mice with Mdmx mutations that prevent modifications by DNA damage-activated kinases. Cancer Cell 16: 33-43. PMCID: PMC2758524 [PDF]
  33. Wade, M., and Wahl, G.M. (2009). Targeting mdm2 and mdmx in cancer: better living through medicinal chemistry? Molecular Cancer Research 7(1): 1-11. PMCID: PMC2629357 [PDF]
  34. Wade M., Rodewald L.W., Espinosa J.M., and Wahl G.M. (2008). BH3 activation blocks Hdmx suppression of apoptosis and co-operates with Nutlin to induce cell death. Cell Cycle 7(13): 1973-82 NIHMSID # 57881. PMCID: PMC2625302. [PDF]
  35. Wang, Y.V., Wade, M., Wong, E.T., Li, Y-C., Rodewald, L.W., and Wahl, G.M. (2007) Quantitative Analyses Reveal the Importance Of Regulated Hdmx Degradation for p53 Activation. Proc. Natl. Acad. Sci. Published Online Before Print July 17, 2007. 104(30):12365-12370. [PDF]
  36. Toledo, F. and Wahl, G.M. (2007) MDM2 and MDM4: p53 Regulators as Targets in Anticancer Therapy. International J Bio. & Cell Biol. doi.org/10.1016/j.biocel.2007.03.022. [PDF]
  37. Toledo, F., Lee, C.J., Krummel, K.A., Liu, C.W., Rodewald, L.W., and Wahl, G.M. (2007) Mouse Mutants Reveal That Putative Protein Interaction Sites in the p53 Proline-Rich Domain are Dispensable for Tumor Suppression. Mol Cell Biol. 27(4):1425–1432. doi: 10.1128/MCB.00999-06. [PDF]
  38. Wade, M., Wong, E.T., Tang, M., Stommel, J.M. and Wahl, G.M. (2006) Hdmx Modulates the Outcome Of p53 Activation in Human Tumor Cells. J Biol. Chem. 281(44):33036-33044. [PDF]
  39. Toledo, F. and Wahl, G.M. (2006) Regulating The p53 Pathway: in vitro Hypotheses, in vivo Veritas. Nat. Rev. Canc. 6:909-923. [PDF]
  40. Wahl, G.M. (2006) Mouse Bites Dogma: How Mouse Models Are Changing Our Views of How P53 Is Regulated in vivo. Cell Death and Differentiation 13:973-983. [PDF]
  41. Wade, M., and Wahl, G.M. (2006) C-myc, Genome Instability, And Tumorigenesis: The Devil is in the Details. Curr. Top. in Microbiol. and Immunol. 302:169-203. [PDF]
  42. Toledo, F., Liu, C.W., Lee, C.J., and Wahl, G.M. (2006) RMCE-ASAP: A Gene Targeting Method for ES and Somatic Cells to Accelerate Phenotype Analyses. Nucleic Acids Research 34(13):e92. [PDF]
  43. Burhans, W., Carr, A.M., and Wahl, G.M. (2006) DNA Replication and Cancer. In DNA Replication And Human Disease (ed. M.L. DePamphilis), pp. 481-500. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York. [HTML]
  44. Toledo, F., Krummel, K.A., Lee, C.J., Liu, C.W., Rodewald, L.W., Tang, M. and Wahl, G.M. (2006) A Mouse p53 Mutant Lacking The Proline-Rich Domain Rescues Mdm4 Deficiency and Provides Insight Into The Mdm2-Mdm4-P53 Regulatory Network. Cancer Cell 9:273-85. [PDF]
  45. Marine, J.C. Francoz, S., Maetens, M., Wahl, G.W., Toledo, F. and Lozano, G. (2006) Keeping P53 In Check: Essential and Synergistic Functions of Mdm2 and Mdm4. Cell Death and Differentiation 13:927–934. doi:10.1038/sj.cdd.4401912. [PDF]
  46. Tang, M., Wahl, G.M. and Nister, M. (2006) Explaining The Biological Activity of Transactivation-Deficient p53 Variants. Nat Genet. 38(4):395-6. [PDF]
  47. Clarke, M.F., Dick, J.E. Dirks, P.B. Eaves, C.J. Jamieson, C.H. Jones, D.L., Visvader, J., Weissman, I.L. and Wahl, G.M. (2006) Cancer Stem Cells–Perspectives On Current Status and Future Directions: AACR Workshop on Cancer Stem Cells. Cancer Res. 66(19):9339-44. [PDF]
  48. Buzina A., M. Aladjem, J. Kolman, G. Wahl and J. Ellis. (2005) Initiation of DNA Replication at the Human ?-Globin 3′ Enhancer. Nucleic Acids Res. 33(14):4412-4424. [PDF]
  49. Wong, E-T., Kolman, J.L., Li, Y-C., and Wahl, G.M. (2005) Reproducible Doxycycline-Inducible Transgene Expression At Specific Loci Generated by Cre-Recombinase Mediated Cassette Exchange. Nucleic Acid Res. 33(17):e147 [PDF]
  50. Krummel, K.A., Toledo, F., Lee, C.J., and Wahl, G.M. (2005) The C-Terminal Lysines Fine-Tune p53 Stress Responses in a Mouse Model, but Are Not Required for Stability Control or Transactivation. Proc. Natl. Acad. Sci. 102:10188-10193. [PDF]
  51. Stommel, J., and Wahl, G.M. (2005) A New Twist in the Feedback Loop: Stress-Activated MDM2 Destabilization Is Required For p53 Activation. (Invited Chapter). Cell Cycle 4(3):411-417. [PDF]
  52. Nistér, M., Tang, M., Zhang, X-Q., Yin, C., Beeche, M., Hu, X., Enblad, G., Van Dyke, T., and Wahl, G.M. (2005) p53 Must Be Competent for Transcriptional Regulation to Suppress Tumor Formation. Oncogene 24:3563-3573. [PDF]
  53. Wahl, G.M., Stommel, J.M., Krummel, K.A., and Wade, M. (2005) Gatekeepers Of The Guardian: p53 Regulation By Post-Translational Modification, Mdm2 And Mdmx. “25 Years of p53 Research”. Editors: Klas Wiman and Pierre Hainaut. Publisher: Springer. Chapter 4:73-113. Printed in the Netherlands. [PDF]
  54. Yamamoto, N., Jiang, P., Yang, M., Xu, M., Yamacuhi, K., Tsuchiya, H., Tomita, K., Wahl, G.M., Moossa, A.R., and Hoffman, R.M. (2004) Cellular Dynamics Visualized in Live Cells in vitro and in vivo By Differential Dual-Color Nuclear-Cytoplasmic Fluorescent-Protein Expression. Cancer Res. 64(12):4251-4256. [PDF]
  55. Thompson, T., Tovar, C., Yang, H., Carvajal, D., Vu, B.T., Xu, Q., Wahl, G.M., Heimbrook, D.C., and Vassilev, L.T. (2004) Phosphorylation of p53 on Key Serines is Dispensable for Transcriptional Activation and Apoptosis. J Biol. Chem. 279(51):53015-53022. [PDF]
  56. Stommel, J. and Wahl, G.M. (2004) Accelerated MDM2 Auto-Degradation Induced by DNA-Damage Kinases is Required for p53 Activation. EMBO Journal. 23:1547-1556. [PDF]
  57. Sears J, Kolman J, Wahl G.M., Aiyar A. (2003) Metaphase Chromosome Tethering is Necessary for The DNA Synthesis And Maintenance Of Orip Plasmids But Is Insufficient for Transcription Activation by Epstein-Barr Nuclear Antigen 1. J Virol. 77(21):11767-80. [PDF]
  58. Tergaonkar,V., Pando, M., Vafa, O., Wahl, G.M. and Verma, I. (2002) p53 Stabilization is Decreased Upon Nf?b Activation: A Role For Nf?b In Acquisition of Resistance to Chemotherapy. Cancer Cell 1(5):493-503. [PDF]
  59. Li, Q., Lee, J.Y., Castillo, R., Hixon, M.S., Pujol, C., Doppalapudi, V.R., Shepard, H.M., Wahl, G.M., Lobl, T., and Chan, M.F. (2002). NB2001, a Novel Antibacterial Agent With Broad-Spectrum Activity and Enhanced Potency Against ?-Lactamase-Producing Strains. Antimicrob. Agents Chemother. 46(5):1262-1268. [PDF]
  60. Neuteboom, S., Karjian, P.L., Boyer, C.R., Beryt, M., Pegram, M., Wahl, G.M., and Shepard, H.M. (2002) Inhibition of Cell Growth By NB1011 Requires High Thymidylate Synthase Levels, And Correlates With P53, P21, Bax and GADD45 Induction. Mol. Cancer Ther. 1:377-384. [PDF]
  61. Vafa, O., Wade, M., Hampton, G.M., Pandita, T.K., and Wahl, G.M. (2002) c-Myc Can Induce DNA Damage, Increase Reactive Oxygen Species, and Mitigate p53 Function: A Mechanism For Oncogene-Induced Genetic Instability. Mol. Cell 9:1031-1044. [PDF]
  62. Aladjem, M., Rodewald, L-W., Lin, C.M., Bowman, S., Cimbora, D.M., Brody, L.L., Epner, E.M., Groudine, M., and Wahl. G.M. (2002) Replication Initiation Patterns In The ?-Globin Loci of Totipotent And Differentiated Murine Cells: Evidence for Multiple Initiation Regions. Mol Cell Biol. 22(2):442-452. [PDF]
  63. Boyer, C.R., Karjian, P.L., Wahl, G.M., Pegram, M., Neuteboom, S. (2002) Nucleoside Transport Inhibitors, Dipyridamole and P-Nitrobenzylthioinosine, Selectively Potentiate the Antitumor Activity of NB1011. Anti-Cancer Drugs 13(1):29-36. [PDF]
  64. Wahl, G.M. and Carr, A.M. (2001) The Evolution Of Diverse Biological Responses to DNA Damage: Insights From Yeast and p53. Nat. Cell. Biol. (Review) 3:E277-E286. [PDF]
  65. Kanda, T., Otter, M. and Wahl, G.M. (2001) Coupling Of Mitotic Chromosome Tethering and Replication Competence in Epstein-Barr Virus-Based Plasmids. Mol. Cell Biol. 21(10):3576-3588. [PDF]
  66. Kanda, T., Otter, M. and Wahl, G.M. (2000) Mitotic Segregation of Viral and Cellular Acentric Extrachromosomal Molecules by Chromosome Tethering. J Cell Science. 114(1):49-58. [PDF]
  67. Wahl, G.M. and Vafa, O. (2000) Genetic Instability, Oncogenes, and the p53 Pathway. Cold Spring Harbor Laboratory LXV: 511-520. [PDF]
  68. Kanda, T. and Wahl, G.M. (2000) The Dynamics of Acentric Chromosomes in Cancer Cells Revealed by GFP-Based Chromosome Labeling Strategies. J Cell Biochem. 79:107-114. [PDF]
  69. Jimenez, G.S., Nister, M., Beeche, M., Stommel, J.M., Barcarse, E., O’Gorman, S., and Wahl, G.M. (2000) A Transactivation-Deficient Mouse Model Provides Insights Into Trp53 Regulation and Function. Nature Genetics 26:37-43.
  70. Khan, S., Moritsugu, J., and Wahl, G.M. (2000) Differential Requirement For P19arf in the p53-Dependent Arrest Induced by DNA Damage, Microtubule Disruption And Ribonucleotide Depletion. Proc. Natl. Acad. Sci. USA 97(7):3266-3271.
  71. Jimenez, G.S., Khan, S.K, Stommel, J., and Wahl, G.M. (1999) p53 Regulation by Post-Translational Modification and Nuclear Retention in Response to Diverse Stresses. Oncogene. 18:7656-7665.
  72. Jimenez, G.S., Bryntesson, F., Torres-Arzayus, M.I., Priestley, A., Beeche, M., Saitoll, S., Sakaguchi, K., Appella, E., Jeggo, P.A., Taccioli, G.E., Wahl, G.M., Hubank, M. (1999) DNA-Dependent Protein Kinase is Not Required for the p53-Dependent Response to DNA Damage. Nature 400:81-83.
  73. Fox, R.I., Herrmann, M.L., Frangou, C.G., Wahl, G.M., Morris, R.E., Kirschbaum, B.J. (1999) REVIEW: Mechanism of Action Leflunomi doi: 10.1128/MCB.00999-06e in Rheumatoid Arthritis. Clin. Immunol
  74. Jiang, X-R., Jimenez, G., Chang, E., Frolis, M., Kusler, B., Sage, M., Beeche, M., Bodnar, A.G., Wahl, G.M., Tlsty, T.D., and Chiu, C-P. (1999) Telomerase Expression in Human Somatic Cells Does Not Induce Changes Associated With a Transformed Phenotype. Nature Genetics 21:111-114.
  75. Stommel, J., Marchenko, N.D., Jimenez, G., Moll, U.M., Hope, T.J., and Wahl, G.M. (1999) A Leucine-Rich Nuclear Export Signal in the p53 Tetramerization Domain: Regulation of Subcellular Localization and p53 Activity by NES Masking. EMBO Journal. 18(6):1660-1672.
  76. Jiang, W., Jimenez, G., Wells, N.J., Hope, T.J., Wahl, G. M., Hunter, T., and Fukunaga, R. (1998) Prc1: A Human Mitotic Spindle-Associated CDK Substrate Protein Required for Cytokinesis. Molecular Cell 2:877-885.
  77. Aladjem, M. I., Rodewald, L. W., Kolman, J. L., and Wahl, G. M. (1998) Genetic Dissection of a Mammalian Replicator in the Human ?-Globin Locus. Science 281:1005-1009.
  78. Kanda T., Sullivan, K.F., and Wahl G.M. (1998) Histone-GFP Fusion Protein Enables Sensitive Analysis of Chromosome Dynamics in Living Mammalian Cells. Current Biology 8:377-385.
  79. Khan, S.H., and Wahl, G.M. (1998) p53 and pRb Prevent Rereplication in Response to Microtubule Inhibitors by Mediating a Reversible G1 Arrest. Cancer Research 58(3):396-401.
  80. Aladjem, M. I., Spike, B. T., Rodewald, L. W., Hope, T. J., Klemm, M., Jaenisch, R., and Wahl, G.M. (1998) ES Cells Do Not Activate p53 Dependent Stress Responses and Undergo p53-Independent Apoptosis in Response to DNA Damage. Current Biology 8:145-155.
  81. Shimizu, N., Itoh, N., Utiyama, H., and Wahl, G.M. (1998) Selective Entrapment of Extrachromosomally Amplified DNA by Nuclear Budding and Micronucleation During S-Phase.
  82. Paulson, T.G., Almasan, A., Brody, L., and Wahl, G.M. (1998) Gene Amplification in a p53-Deficient Cell Line Requires Cell Cycle Progression Under Conditions That Generate DNA Breakage. Mol. Cell. Biol. 18(5):3089-3100.
  83. Aladjem, M. and Wahl, G.M. (1998) Mapping Replication Fork Direction by Leading Strand Analysis. Methods: A companion to Methods in Enzymology 13(3):281-292.
  84. Linke, S.P., Harris, M.P., Neugebauer, S.E., Clarkin, K.C., Shepard, H.M., Maneval, D.C., and Wahl, G.M. (1997) p53-Mediated Accumulation of Hypophosphorylated prb After the G1 Restriction Point Fails to Halt Cell Cycle Progression. Oncogene 15:337-345.
  85. Di Leonardo, A., Hussain-Khan, S., Linke, S.P., Greco, V., Seidita, G., and Wahl, G.M. (1997) DNA Rereplication in the Presence of Mitotic Spindle Inhibitors in Human and Mouse Fibroblasts Lacking Either p53 or prb Function1. Cancer Research 57:1013-1019.
  86. Linke, S.P., Clarkin, K., and Wahl, G.M. (1997) p53 Mediates Permanent Arrest Over Multiple Cell Cycles In Response to ?? Irradiation1. Cancer Research 57:1171-1179.
  87. Wahl, G.M., Linke, S.P., Paulson, T.G., and Huang, L-c. (1997) Checkpoint Controls and Cancer: Maintaining Genetic Stability Through Tp53 Mediated Checkpoint Control. In J. Tooze (ed.), Cancer Surveys. Cold Spring Harbor Laboratory Press, New York 29:183-219.
  88. Wahl, G.M., Linke, S.P., Paulson, T.G., and Huang, L-C. (1997) Cell Cycle Control of Genetic Stability, in Genomic Instability and Immortality in Cancer: Mammalian Checkpoints and Genetic Instability. In Enrico Mihich (ed.), Proceedings of the 8th Annual Pezcoller Symposium, June 17-19, 1996, Trento, Italy. Plenum Publishing Co., New York 8:33-52
  89. Aladjem, M., Brody, L., O’Gorman, S., and Wahl, G.M. (1997) Positive Selection of FLP Mediated Unequal Sister Chromatid Exchange Products In Mammalian Cells. Mol. Cell. Biol. 17:857-861.
  90. Jones, S.N., Sands, A.T., Hancock, A.R., Vogel, H., Donehower, L.A., Linke, S.P., Wahl, G.M., Bradley, A. (1996) Absence of a p53-independent role for Mdm2 in control of cell growth and tumorigenesis. Proc. Natl. Acad. Sci. USA 93:14106-14111.
  91. Paulson, T.G., Wright, F., Parker, B., Russack, V., and Wahl, G.M. (1996) Microsatellite Instability Correlates With Reduced Survival and Poor Disease Prognosis in Breast Cancer. Cancer Research 56:4021-4026.
  92. Huang, L-c., Clarkin, K., and Wahl, G.M. (1996) p53 Dependent Cell Cycle Arrests Are Preserved in DNA-Activated Protein Kinase Deficient Mouse Fibroblasts. Cancer Research 56:2940-2944.
  93. Linke, S.P., Clarkin, K., DiLeonardo, A., Tsou, A., and Wahl, G.M. (1996) A Reversible, p53-Dependent G0/G1 Cell Cycle Arrest Induced by Ribonucleotide Depletion in the Absence of Detectable DNA Damage. Genes and Development 10: 934-947.
  94. Huang, L-C., Clarkin, K.C., and Wahl, G.M. (1996) Sensitivity And Selectivity of the DNA Damage Sensor Responsible for Activating p53-Dependent G1 Arrest. Proc. Natl. Acad. Sci. USA. 93(10):4827-4832.
  95. Shimizu, N., Kanda, T., and Wahl, G.M. (1996) Selective Capture of Acentric Fragments by Micronuclei Provides a Rapid Method for Purifying Extrachromosomally Amplified DNA. Nature Genetics. 12:65-71.
  96. Aladjem, M., Groudine, M., Brody, L., Dieken, E., Fournier, R.E., Wahl, G.M., and Epner, E. (1995) Participation of the Human ?-Globin Locus Control Region in Initiation of DNA Replication. Science 270:815-819.
  97. Li, W., Fan, J., Zielinski, Z., Almasan, A., Yin, Y., Kelly, R., Wahl, G.M., Bertino, J.R. (1995) Lack of Functional Retinoblastoma Protein Mediates Increased Resistance to Antimetabolites in Human Sarcoma Cell Lines. Proc. Natl. Acad. Sci. USA. 92:10436-10440.
  98. Kelly, R., DeRose, M.L., Draper, B., and Wahl, G.M. (1995) Identification of an Origin of Bidirectional DNA Replication in the Ubiquitously Expressed Mammalian CAD Gene. Mol. Cell. Biol. 15(8):4136-4148.
  99. Almasan, A., Yin, Y., Kelly, R., Lee, E.Y.-H., Bradley, A., Wahl, G.M. (1995) Deficiency of Retinoblastoma Protein Leads to Inappropriate S-Phase Entry, Activation of E2F-Responsive Genes, and Apoptosis. Proc. Natl. Acad. Sci. 92:5436-5440.
  100. Almasan, A., Linke, S.P., Paulson, T.G., Huang, L-c., Wahl, G.M. (1995) Genetic Instability as a Consequence of Inappropriate Entry Into and Progression Through S-Phase. Cancer Metastasis Reviews. 14: 59-73.
  101. Van Den Berg, C.L., McGill, J.R., Kuhn, J.G., Walsh, J.T., De La Cruz, P.S., Davidson, K.K., Wahl, G.M., Von Hoff, D.D. (1994) Pharmacokinetics of Hydroxyurea in Nude Mice. Anti Cancer Drugs. 5: 573-578.
  102. Di Leonardo, A., Linke, S.P., Clarkin, K., Wahl, G.M. (1994) DNA Damage Triggers a Prolonged P53-Dependent G1 Arrest and Long-Term Induction of Cip1 in Normal Human Fibroblasts. Genes and Development 8: 2540-2551.
  103. Eckhardt, S.G., Dai, A., Davidson, K.K., Forseth, B.J., Wahl, G.M., Von Hoff, D.D. (1994) Induction Of Differentiation in HL60 Cells by the Reduction of Extrachromosomally Amplified
  104. DiLeonardo, A., Linke, S.P., Yin, Y., Wahl, G.M. (1994) Cell Cycle Regulation of Gene Amplification. Cold Spring Harbor Symp. Quant. Biol. 58: 655-667.
  105. Almasan, A., Mangelsdorf, D.J., Ong, E.S., Wahl, G.M., Evans, R.M. (1994) Chromosomal Localization of the Human Retinoid X Receptors. Genomics 20:397-403.
  106. Barclay, B.J., Ondrusek, N.K., Wildenhain, Y.D., Huang, T., Carlone, R.L., Clement, J-M., Wahl, G.M. (1993) Effect Of Genomic Position on Amplification of the DFR1 Gene in Saccharomyces Cerevisiae. In Chemistry and Biology of Pteridines And Folates. Eds. J. Ayling, M. Nair and C. Baugh, Plenum Press, New York. 338: 545-550.
  107. Carroll, S. M., DeRose, M.L., Kolman, J.L., Nonet, G. H., Kelly, R.E., and Wahl, G.M. (1993) Localization of a Bidirectional DNA Replication Origin in Native Locus and in Episomally Amplified Murine Adenosine Deaminase Loci. Mol. Cell. Biol. 13: 2971-2981.
  108. Nonet, G. and Wahl, G.M. (1993) Introduction of YACs Containing a Putative Mammalian Replication Origin Into Mammalian Cells Can Generate Structures That Replicate Autonomously. Somatic Cell Mol. Genet. 19:171-192.
  109. VonHoff, D.D., McGill, J.R., Forseth, B.J., Davidson, K.K., Bradley, T.P., Van Devanter, D.R., and Wahl, G.M. (1992) Elimination of Extrachromosomally Amplified C-Myc Genes From Human Tumor Cells Reduces Their Tumorigenicity. Proc. Natl. Acad. Sci. 89: 8165-8169.
  110. Nonet, G.H., Carroll, S.M., DeRose, M.L., Wahl, G.M. (1993) Molecular Dissection of an Extrachromosomal Amplicon Reveals a Circular Structure Consisting of an Imperfect Inverted Duplication. Genomics 15: 543-558.
  111. Yin, Y., Tainsky, M.A., Bischoff, F.Z., Strong, L. C. and Wahl, G.M. (1992) Wild-type p53 Restores Cell Cycle Control And Inhibits Gene Amplification in Cells With Mutant p53 Alleles. Cell 70:937-948.
  112. Windle, B.E. and Wahl, G.M. (1992) Molecular Dissection of Mammalian Gene Amplification: New Mechanistic Insights Revealed by Analyses of Very Early Events. Mutat. Res. 276:199-224.
  113. Kimmel, M., Axelrod, D.E. and Wahl, G.M. (1992) A Branching Process Model of Gene Amplification Following Chromosome Breakage. Mutat. Res. 276: 225-239.
  114. Wahl, G.M., Carroll, S. M., and Windle, B.E. (1992) Cytogenetic and Molecular Dynamics of Mammalian Gene Amplification: Evidence Supporting Chromosome Breakage as an Initiating Event. In Gene Amplification in Mammalian Cells: A Comprehensive Guide R. Kellems, Ed., Marcel Dekker, Inc., New York, pages 513-531.
  115. Von Hoff, D.D., Waddelow, T., Forseth, B., Davidson, K., Scott, J. and Wahl, G.M. (1991) Hydroxyurea Accelerates Loss of Extrachromosomally Amplified Genes from Tumor Cells. Cancer Research 51:6273-6279.
  116. Carroll, S., Trotter, J. and Wahl, G.M. (1991) Replication Timing Control Can be Maintained in Extrachromosomally Amplified Genes. Mol. Cell. Biol. 11:4779-4785.
  117. Benner, S.E., Wahl, G.M. and Von Hoff, D.D. (1991) Double Minute Chromosomes and Homogeneously Staining Regions in Tumors Taken Directly From Patients Versus in Human Tumor Cell Lines. Anticancer Drugs 2:11-25.
  118. O’Gorman, S., Fox, D.T. and Wahl, G.M. (1991) Recombinase-Mediated Gene Activation and Site-Specific Integration in Mammalian Cells. Science 251:1351-1355.
  119. Windle, B., Draper, B., Yin, Y., O’Gorman, S. and Wahl, G.M. (1991) A Central Role for Chromosome Breakage In Gene Amplification, Deletion Formation and Amplicon Integration. Genes and Dev. 5:160-174.
  120. Barringer, K.J., Orgel, L., Wahl, G.M. and Gingeras, T.R. (1990) Blunt-end and Single-strand Ligation by Escherichia coli Ligase: Influence on an in vitro Amplification Scheme. Gene 89:117-122.
  121. Ruiz, J. and Wahl, G.M. (1990) Chromosome Destabilization During Gene Amplification. Mol. Cell. Biol. 10:3056-3066.
  122. Stark, G.R., Debatisse, M., Giulotto E. and Wahl, G.M. (1989) Recent Progress in Understanding Mechanisms of Mammalian DNA Amplification. Cell 57:901-908.
  123. Stark, G.R., Debatisse, M., Wahl, G.M. and D. Glover (1989) DNA Amplification in Eukaryotes. IRL Press, B.D. Hanes and D.M. Glover (eds.) Gene Rearrangement, pp 99-149.
  124. Wahl, G.M. (1989) The Importance of Circular DNA in Mammalian Gene Amplification. Cancer Research 49:1333-1340.
  125. Ruiz, J., Choi, K., Von Hoff, D.D., Roninson, I.B. and Wahl, G.M. (1989) Autonomously Replicating Episomes Contain mdr-1 Genes in a Multidrug Resistant Human Cell Line. Mol. Cell. Biol. 9:109-115.
  126. Barclay, B.J., Huang, T., Nagel, M.G., Misener, V.L., Game, J.C., and Wahl, G.M. (1988) Mapping and Sequencing of the Dihydrofolate Reductase Gene (DFR1) of Saccharomyces cerevisiae. Gene 63:175-185.
  127. Ruiz, J.C. and Wahl, G.M. (1988) Formation of an Inverted Duplication Can be an Initial Step in Gene Amplification. Mol. Cell. Biol. 8:4302-4313.
  128. Von Hoff, D.D., Needham-Vandevanter, D.R., Yucel, J., Windle, B.F. and Wahl, G.M. (1988) Amplified MYC Oncogenes Localized to Replicating Submicroscopic, Circular DNA Molecules. Proc. Natl. Acad. Sci. USA 85: 4804-4808.
  129. Carroll, S., DeRose, M.L., Gaudray, P., Moore, C., Vandevanter, D.N., Von Hoff, D.D. and Wahl, G.M. (1988) Double Minute Chromosomes Can be Produced From Precursors Derived From a Chromosomal Deletion. Mol. Cell. Biol. 8:1525-1533.
  130. Carroll, S., Gaudray, P., DeRose, M.L., Emery, J.F., Meinkoth, J.L., Nakkim, E., Subler, M. and Wahl, G.M. (1987). Characterization of an Episome Produced in Hamster Cells that Amplify a Transfected CAD Gene at High Frequency: Functional Evidence for a Mammalian Replication Origin. Mol. Cell Biol. 7:1740-1750.
  131. Wahl, G.M., Lewis, K.A., Ruiz, J.C., Rothenberg, B., Zhao, J. and Evans, G. (1987) Cosmid Vectors for Rapid Genomic Walking, Restriction Mapping and Gene Transfer. Proc. Natl. Acad. Sci. USA 84:2160-2164.
  132. Meinkoth, J.L., Killary, A., Fournier, R.E.K. and Wahl, G.M. (1987) Unstable and Stable CAD Gene Amplification: Importance of Flanking Sequences and Nuclear Environment in Gene Amplification. Mol. Cell. Biol. 7:1415-1424.
  133. Wahl, G.M., Carroll, S.M., Gaudray, P., deRose, M.L., Emery, J. and Von Hoff, D.D. (1987) High Frequency Amplification of a Transfected Gene via Excision of an Autonomously Replicating Episome. In Proceedings of the Workshop on the Role of DNA Amplification in Tumor Initiation and Promotion. (H. zur Hausen and J.R. Schlehofer, Eds.) J. B. Lippincott Co., Philadelphia, pp. 45-57.
  134. Evans, G.A. and Wahl, G.M. (1987) Cosmid Cloning Vectors: In Guide to Molecular Cloning Techniques, Methods in Enzymology Vol. 152 (S.L. Berger and A.R. Kimmel, Eds.) New York Academic Press: Chapter 65: 604-610. Cosmid Vectors for Genomic Walking and Rapid Restriction Mapping.
  135. Wahl, G.M., Meinkoth, J. and Kimmel, A.R. Chapter 61, 572-581. Northern and Southern Blots.
  136. Wahl, G.M. and Berger, S.L. Chapter 45, 415-423. Screening Colonies or Plaques with Radioactive Nucleic Acid Probes.
  137. Wahl, G.M., Berger, S.L., Kimmel, A.R. Chapter 43, 91-94. Molecular Hybridization of Immobilized Nucleic Acids: Theoretical Concepts and Practical Considerations.
  138. Meinkoth, J. and Wahl, G.M. (1987) Chapters concerning Nucleic Acid Hybridization in Guide to Molecular Cloning Techniques, Methods in Enzymology Vol. 152 (S.L. Berger and A.R. Kimmel, Eds.) New York Academic Press: Chapter 9, 399-407. Nick Translation.
  139. Wahl, G.M. and Richman, D.D. (1986). Nucleic Acid Probes to Detect Viral Diseases. In: Concepts in Viral Pathogenesis. (A.L. Notkins and M.B.A. Oldstone, Eds.) Springer-Verlag, New York, pp. 301-309.
  140. Wahl, G.M., Carroll, S., Gaudray, P., Meinkoth, J. and Ruiz, J. (1986). Applications of Gene Transfer in the Analysis of Gene Transfer in the Analysis of Gene Amplification. In: Gene Transfer (R. Kucherlapati, ed), Plenum Publishing Corp., pp. 289-323.
  141. Wahl, G.M., Gaudray, P., Carroll, S. and Proctor, N. (1986) Is Gene Amplification Inducible? In: R. Dulbecco, V. De Vita, L. Santi, L. Zardi, eds. Cancer Frontiers, Proceedings of the Second International Conference on Progress in Cancer Research. The Humana Press, pp. 71-98.
  142. Ruiz, J.C. and Wahl, G.M. (1986) Escherichia Coli Aspartate Transcarbamylase: A Novel Marker for Studies of Gene Amplification and Expression in Mammalian Cells. Mol. Cell. Biol. 6:3050-3058.
  143. Meinkoth, J.L., Legouy, E., Brison, O. and Wahl, G.M. (1986) New RNA Species is Produced by Alternate Polyadenylation Following a Rearrangement Associated with CAD Gene Amplification. Som. Cell and Mol. Genet. 12:339-350.
  144. Gaudray, P., Trotter, J. and Wahl, G.M. (1986). Fluorescent Methotrexate Labeling and Flow Cytometric Analysis of Cells Containing Low Levels of Dihydrofolate Reductase. J. Biol. Chem. 261:6285 – 6292.
  145. Wahl, G.M. (1985) Detection of Adventitious Agents and Sensitivity of Methods. In: Abnormal Cells, New Products and Risk. Hopps, H.E. and Petricciani, J.C., eds. Tissue Culture Association, Gaithersburg, Maryland.
  146. Wahl, G.M., Albanil, S., Ignacio, K. and Richman, D.D. (1985) Nucleic Acid Hybridization: A Powerful Technology Useful for Medical Diagnosis, pp 31-64. In: Medical Virology IV, de la Maza, L.M. and Peterson, E.M., eds. Lawrence Erlbaum Associates, Publishers, Hillsdale, New Jersey.
  147. Meinkoth, J. and Wahl, G.M. (1984) Hybridization of Nucleic Acids Immobilized on Solid Supports. Analytical Biochemistry 138:267-284.
  148. Stark, G.R. and Wahl, G.M. (1984) Gene amplification. Ann. Rev. Biochem. Annual Reviews of Biochemistry 53: 447-491.
  149. Wahl, G.M., Allen, V., Delbruck, S., Eckhart, W., Meinkoth, J., Robert de Saint Vincent, B., and Vitto, L. (l984) Analysis of CAD Gene Amplification Using a Combined Approach of Molecular Genetics And Cytogenetics. In “Eukaryotic Cell Cultures: Basics and Applications.” Edited by Ronald T. Acton and J. Daniel Lynn, Plenum Press, New York and London. Advances in Experimental Medicine and Biology, Vol. 172:319-345.
  150. Richman, D.D., Cleveland,P.H., Redfield, D.C., Oxman, M.N. and Wahl, G.M. (1984) Rapid Viral Diagnosis. J. Infec. Diseases 149:298-310.
  151. Wahl, G.M., Robert de Saint Vincent, B. and De Rose, M.L. (l984) Effect of Chromosomal Position on Amplification of Transfected Genes in Animal Cells. Nature 307:516-520.
  152. Wahl, G.M., Vitto, L., and Rubnitz, J. (l983) Co-amplification of rRNA Genes with CAD Genes in N-(Phosphonacetyl)-L-Aspartate-resistant Syrian Hamster Cells. Mol. Cell. Biol. 3:2066-2075.
  153. Redfield, D.C., Richman, D.D., Albanil, S., Oxman, M. and Wahl, G.M. (l983) Detection of Herpes Simplex Virus in Clinical Specimens by DNA Hybridization. Diagnostic Micro. and Infectious Dis. l:ll7-l28.
  154. Robert de Saint Vincent, B., and Wahl, G.M. (l983) Homologous Recombination in Mammalian Cells Mediates the Formation of a Functional Gene From Two Overlapping Gene Fragments. Proc. Natl. Acad. Sci. USA 80:2002-2006.
  155. Chu, B.C.F., Wahl, G.M. and Orgel, L.E. (1983) Derivatization of Unprotected Polynucleotides. Nucl. Acids Res. 11:6513-6529.
  156. Padgett, R.A., Wahl, G.M., Brison, O., and Stark, G.R. (l982) Use of Recombinant DNA Techniques to Examine Amplified Regions of DNA From Drug-Resistant Mutant Cells, p. l09-l3l. In A.G. Walton (ed.) Third Cleveland Symposium on Macromolecules-Recombinant DNA. Elsevier Scientific Publishing Co., Amsterdam.
  157. Wahl, G.M., Allen, V., Delbruck, S., Eckhart, W., Meinkoth, J., Padgett, R., Robert de Saint Vincent, B., Rubintz, J., Stark, G.R. and Vitto, L. (l982) Analysis of CAD Gene Amplification Using Molecular Cloning, Gene Transfer and Cytogenetics. In Gene Amplification (R.T. Schimke, ed.) Cold Spring Harbor Laboratory, pp. l67-l75.
  158. Folger, K.R., Wong, E.A., Wahl, G.M. and Capecchi, M.R. (l982) Patterns of Integration of DNA Microinjected Into Cultured Mammalian Cells: Evidence for Homologous Recombination Between Injected Plasmid DNA Molecules. Mol. Cell Biol. 2:l372-l387.
  159. Padgett, R.A., Wahl, G.M., and Stark, G.R. (l982) Properties Of Dispersed, Highly Repeated DNA Within and Near the Hamster CAD Gene. Mol. Cell. Biol. 2:302-307.
  160. Padgett, R.A., Wahl, G.M., and Stark, G.R. (l982) Structure of the Gene for CAD, the Multifunctional Protein That Initiates UMP Synthesis in Syrian Hamster Cells. Mol. Cell. Biol. 2:293-30l.
  161. Wahl, G.M., Vitto, L., Padgett, R.A., and Stark, G.R. (l982) Single-Copy and Amplified CAD Genes in Syrian Hamster Chromosomes Using A Highly Sensitive Method for in Situ Hybridization. Mol. Cell. Biol. 2:308-3l9.
  162. Robert de Saint Vincent, B., Delbruck, S., Eckhart, W., Meinkoth, J., Vitto, L., and Wahl, G. (l98l) Cloning and Reintroduction Into Animal Cells of a Functional CAD Gene, a Dominant Amplifiable Genetic Marker. Cell 27:267-277.
  163. Kohli, J., Altruda, F., Kwong, T., Rafalski, A., Wetzel, R., Soll, D., Wahl, G.M., and Leupold, U. (l980) Nonsense Suppressor tRNA in Schizosaccharomyces Pombe. tRNA: Biological Aspects, Cold Spring Harbor Quant. Biol. 407-4l9.
  164. Alwine, J.C., Kemp, D.J., Parker, B.A., Reiser, J., Renart,J., Stark, G.R., and Wahl, G.M. (l979) Detection of Specific Rnas or Specific Fragments of DNA by Fractionation In Gels And Transfer To Diazobenzyloxymethyl Paper. Methods in Enzymology 68:220-242.
  165. Wahl, G.M., Stern, M., and Stark, G.R. (l979) Efficient Transfer of Large DNA Fragments From Agarose Gels to Diazobenzyloxymethyl-Paper and Rapid Hybridization by Using Dextran Sulfate. Proc. Natl. Acad. Sci. USA 76:3683-3687.
  166. Wahl, G.M., Padgett, R.A., and Stark, G.R. (l979) Gene Amplification Causes Overproduction of the First Three Enzymes of UMP Synthesis In N- (Phosphonacetyl)-L- Aspartate-Resistant Hamster Cells. J. Biol. Chem. 254:8679-8689.
  167. Padgett, R.A., Wahl, G.M., Coleman, P.F., and Stark, G.R. (l979) N- (Phosphonacetyl)-L-Aspartate-Resistant Hamster Cells Over Accumulate a Single mRNA Coding for the Multifunctional Protein That Catalyzes the First Steps of Ump Synthesis. J. Biol. Chem. 254:974-980.
  168. Kohli, J., Kwong, T., Altruda, F., Soll, D. (Yale University), and Wahl, G.M. (University of Utah) (l979) Characterization of a UGA-Suppressing Serine ?RNA From Schizosaccharomyces Pombe With the Help of a New In Vitro Assay System for Eukaryotic Suppressor ?RNA’s. J. Biol. Chem. 254:l546-l55l.
  169. Capecchi, M.R., Hughes, S.H. and Wahl, G.M. (l975) Yeast Super- Suppressors are Altered ?RNA’s Capable of Translating a Nonsense Codon in vitro. Cell 6:269-277.
  170. Wahl, G.M., Hughes, S.H. and Capecchi, M.R. (l975) Immunological Characterization of Hypoxanthine-Guanine Phosphoribosyl Transferase Mutants of Mouse L Cells: Evidence for Mutations at Different Loci in the HGPRT Gene. J. Cell. Physiol. 85:307-320.
  171. Hughes, S.H., Wahl, G.M. and Capecchi, M.R. (l975) Purification and Characterization of Mouse Hypoxanthine-Guanine Phosphoribosyl Transferase. J. Biol. Chem. 250:l20-l26.
  172. Capecchi, M.R., Capecchi, N.E., Hughes, S.H. and Wahl, G.M. (l974) Selective Degradation of Abnormal Proteins in Mammalian Tissue Culture Cells. Proc. Nat. Acad. Sci. USA 71: 4732-4736.
  173. Sigman, D.S., Wahl, G.M., and Creighton, D.J. (l972) Models for Metalloenzymes. Zinc ion Catalyzed Phosphorylation of l, l0- Phenanthroline-2-Carbinol by Adenosine Triphosphates. Biochem. ll:2236- 224l.
  174. Evans, D.A., Bryan, C.A. and Wahl, G.M. (l970) Total Synthesis of Naturally Occurring Substances. The Synthesis of the Hasubanan Carbocyclic System. J. Org. Chem. 35: 4l22-4l26.