Postdoctoral Position- Gene Expression Laboratory

Job #: E793
Closes On: Open Until Filled
Job Title: Postdoctoral Position
Status: Regular Full Time
Benefits Eligible: Yes
Laboratory/Department: Gene Expression Laboratory

The research focuses on important problems related to cancer initiation, detection, progression, metastasis and treatment. These projects are based on our recent observations concerning cell state plasticity that arises during cancer progression. Specifically, we are using a single cell RNA sequencing, epigenetic profiling, and developing novel in vivo and in vitro strategies to determine how breast cancer cells undergo developmental reprogramming to generate intra-tumoral heterogeneity and metastasis. Our long-term goals are to devise novel strategies to intercept such cells, to reduce the probability that drug resistant or metastatic clones will arise or spread.

Recent publications include:
Giraddi et al, 2018, Cell Reports:
Dravis et al, 2018, Cancer Cell:
Wahl and Spike, 2017, NPJ Breast Cancer:
Dravis et al, 2015, Cell Reports:

Position Description:
THREE Funded post-doctoral positions are immediately available for individuals with a good grounding in molecular and/or developmental biology, methods such as CRISPR mediated genome editing, RNA-sequencing and epigenetics. One position is available for a person with expertise in bioinformatics, especially as relates to single cell data sets (ATAC-seq, RNA-seq) etc.. Ideal candidates should be intellectually curious, productive, and enjoy working in a committed team effort to make these important projects succeed. The projects are well under way due to the efforts of a dedicated group of post-docs, technicians and undergrads.

Ph.D. in Biological Sciences, computational biology, or related fields; M.D./PhD highly encouraged to apply.

Experience with computational biology, and/or developmental biology, epigenetics, molecular and embryologic techniques such as immunohistochemistry, in situ hybridization, RNA-sequencing, single cell methods for transcriptional analysis, ATAC-seq, PCR, and mouse genetic manipulations are highly desired.

Application Instructions:
Applicants should submit a current CV, names of three references, and an indication of the experimental direction they would like to pursue based on their reading of our recent papers. Send applications to:

Contact Information:
Geoffrey M. Wahl, Ph.D
The Salk Institute for Biological Studies
Gene Expression Laboratory
10010 N. Torrey Pines Road
La Jolla, CA 92037
Fax: (858) 457-2762